TCI : Target Controlled Infusion, or Totally Confused Infusion? Call for an Optimised Population Based Pharmacokinetic Model for Propofol.

Target Controlled Infusion (TCI)

Total Intravenous Anaesthesia in dogs: Development of a Target Controlled Infusion (TCI) scheme for propofol

Cross-simulation between two pharmacokinetic models for the target-controlled infusion of propofol

BACKGROUND We investigated how one pharmacokinetic (PK) model differed in prediction of plasma (C(p)) and effect-site concentration (C(eff)) using a reproducing simulation of target-controlled infusion (TCI) with another PK model of propofol. METHODS Sixty female patients were randomly assigned to TCI using Marsh PK (Group M) and TCI using Schnider PK (Group S) targeting 6.0 µg/ml of C(p) of ...

A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval

OBJECTIVE To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval. METHODS Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effect-site concentration of 1.5 μg/mL was instituted. The pat...

Science vs supposition: the case of target-controlled propofol infusion.

Editor—I continue to be confounded by the use of target-controlled propofol infusion (TCI) dosing paradigm as an accepted basis for presenting the scientific study in anaesthesia journals without specific documentation of instantaneous and total dose infusion rates, in conjunction with body weight and duration of infusion at the study point. Although TCI may be utilitarian in the clinical admin...